Fibrous papule aka solitary angiofibroma is a common benign skin growth. As a solitary lesion, there are no associated systemic implications. When multiple angiofibromas are seen in an individual, particularly clustered over the central face, the differential diagnosis should include the tuberous sclerosis complex, and appropriate evaluation should ensue to assess the patient for tuberous sclerosis. Multiple facial angiofibromas may also be seen as the presenting sign or in association with multiple endocrine neoplasia type 1. Solitary fibrous papule presents as a red to skin-colored firm papule arising on the face, most commonly on the nose Figure 1. It is usually small, less than 5 mm, and found in middle-aged adults.
Facial angiofibromas treated with topical rapamycin: An excellent choice with fast response
Laser therapy has been used with good responses but it is a painful option and recurrence is guaranteed. This eventually induces formation of hamartomatous tumors in patients with TSC. An excellent response was achieved surprisingly rapidly. An year-old girl with a personal history of tuberous sclerosis ST came to our hospital.