Pathway of breast cancer

Stmn1 Stathmin-1 also referred to as Op18 Oncoprotein is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly expressed in a wide variety of cancers and its high abundance seems to be necessary for the maintenance of the transformed phenotypes. Breast cancers exhibit high levels of Stmn1 and may be resistant to anti-microtubule agents. Stmn1 destabilizes microtubule polymers of Alpha-Tubulin and Beta-Tubulin subunits, by promoting catastrophes that ultimately results in deregulation of cell cycle, hampering cell survival Ref.
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Early and locally advanced breast cancer overview

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The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers

Select Species: Human Mouse Rat. Your Price : Log In. These panels are a focused compilation of genes based on their role in a biological process, disease, or pathway. Targets represent a diverse set of signaling molecules as well as upstream and downstream effectors. Qiagen is not affiliated with Bio-Rad Laboratories, Inc. All users agree that a no right, title or interest in the Maps is transferred by display of the Maps; b the Maps may only be used for purposes of determining whether to purchase Bio-Rad products and services displayed in relation to the Maps; c the Maps may not be copied, printed, downloaded, modified or disassembled, and no derivatives of the Maps may be created; d the Maps and the data contained in the Maps may not be used for purposes of development or commercialization of any third party product or service without first obtaining a separate written license for such use from Thomson Reuters Scientific Inc. Target Details Click on a target from the pathway image to view related information.
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The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers

January 25, Researchers at Kanazawa University report in Proceedings of the National Academy of Sciences PNAS that a particular signaling pathway in breast cancer tumors causes cancer cells to divide symmetrically, expanding the tumor. Inhibiting the pathway with drugs could become a strategy for eliminating the cancer cells. In breast cancer , one of the most common cancers in women, tumors contain a small amount of so-called cancer stem-like cells CSCs. Eliminating breast cancer stem-like cells in a targeted way is essential for developing successful therapies— conventional treatments , such as chemotherapy or radiotherapy followed by drug intake, do not target CSCs.
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Triple-negative breast cancer TNBC is characterised by poor outcomes and a historical lack of targeted therapies. Recent randomised trials suggest improved progression-free survival PFS with AKT-inhibitors in combination with first-line chemotherapy for patients with TNBC and pathway genetic aberrations. We discuss uncertainty over defining which cancers have pathway activation and the future overlap between immunotherapy and pathway targeting.
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