Invasive pleomorphic lobular breast cancer

Hi I am Had my first mammogram and they found a lesion. Had biopsy and they told me my cells were changing and I was high risk for breast cancer. Had op to remove it. When I got patholit report back they found I had a rare cancer.
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Invasive Lobular Carcinoma

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Invasive lobular carcinoma - Diagnosis and treatment - Mayo Clinic

Invasive pleomorphic lobular carcinoma PLC is an aggressive subtype of invasive lobular carcinoma of the breast, which has its own histopathological and biological features. The metastatic patterns for PLC are distinct from those of invasive ductal carcinoma. In addition, pancreatic metastasis from PLC is extremely rare. We report a rare case of a year-old woman presenting with clinical gastrointestinal symptoms and pancreatic metastasis of PLC. The pancreatic tumor was composed of pleomorphic tumor cells arranged in the form of solid sheets and nests and as single files, with frequent mitotic figures, nucleolar prominence, high nuclear to cytoplasmic ratio and loss of cohesion. The malignant cells were positive for p cytoplasmic and GATA3 and negative for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, E-cadherin, gross cystic disease fluid protein 15 and mammaglobin, which indicated a lobular carcinoma phenotype of the breast. To the best of our knowledge, this is one of the few reported cases in the literature of pancreatic metastasis of invasive lobular carcinoma of the breast, of which the definitive diagnosis was obtained only after surgery.
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Pleomorphic Breast Cancer

Subscribe to our What's New in Pathology newsletter - next issue on Hematopathology coming out soon. Podoll, M. Reisenbichler, M. Page views in 4, Cite this page: Podoll, M.
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Pleomorphic carcinoma is a poorly described entity whose phenotype is not well recognized as within the morphological spectrum of breast carcinoma. The purpose of this report is to describe the clinicopathological features of this tumour with review of the literature. We report a case of invasive pleomorphic lobular carcinoma with coexisting classic lobular carcinoma in situ.
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