In a typical stem cell transplant for cancer very high doses of chemo are used, sometimes along with radiation therapy , to try to kill all the cancer cells. This treatment also kills the stem cells in the bone marrow. Soon after treatment, stem cells are given to replace those that were destroyed. These stem cells are given into a vein, much like a blood transfusion. Over time they settle in the bone marrow and begin to grow and make healthy blood cells.
Potential therapy identified for aggressive breast cancer
Stem cell therapy attacks cancer by targeting unique tissue stiffness -- ScienceDaily
High dose chemotherapy and radiation can severely damage or destroy your bone marrow while killing cancer cells. Without healthy bone marrow, your body is no longer able to make the blood cells needed to prevent infection, bleeding, and carry oxygen. Stem cell transplants replace the stem cells destroyed by high dose cancer treatment allowing your bone marrow to produce healthy cells. In autologous stem cell transplants, you are your own donor. Your bone marrow or peripheral blood stem cells are taken from you harvested , frozen until needed, then given back to you transplanted after you have received high doses of chemotherapy, radiation or both to destroy your cancer cells. The allogeneic stem cell transplant is when your bone marrow and immune system are replaced with new, healthy bone marrow or peripheral blood stem cells from another person. Traditionally, most allogeneic stem cell transplants have been performed using stem cells from the bone marrow, but the use of peripheral blood stem cells is increasing.
Stem cell therapy attacks cancer by targeting unique tissue stiffness
August 30, , by NCI Staff. Researchers have developed a treatment that targets stiff components of the extracellular matrix blue surrounding metastatic cancer cells red as a potential therapy for metastatic cancer. Researchers have used modified stem cells to deliver a cancer drug selectively to metastatic breast cancer tumors in mice.
Investigators from Massachusetts General Hospital MGH and the Harvard Stem Cell Institute have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study published online in the journal Brain also describes a strategy of preventing the potential negative consequences of stem cell therapy. Tagged therapeutic stem cells green targeting breast cancer metastases red in the brain of a mouse model.